The Lupus Research Alliance (LRA) and the National Minority Quality Forum formed the Lupus Multi-Cultural Engagement Partnership (Lupus MCEP) in 2017 to address the causes and potential solutions for the lack of inclusion in clinical trials of populations that are at greatest risk for and have the highest prevalence of Systemic Lupus Erythematosus (SLE or lupus). The inaugural Lupus MCEP meeting featured presentations from researchers, clinicians, people with lupus, and patient advocates who described the complexity of the Lupus MCEP charge through their particular lenses.