February 22, 2024
By NMQF Staff
For Immediate Release
May 23, 2006 | WASHINGTON, D.C.
Foundation Announces Collaboration on Clinical Trial Targeting Cardiovascular Risks
Patient Enrollment Efforts Target At-Risk African Americans
The National Minority Health Month Foundation (The Foundation) and deCODE Genetics, Inc. announced today a collaborative effort to support patient enrollment in the Leukotrienes in African American Patients with Coronary Artery Disease trial (LTCAD study). This multi-center trial is unique by focusing on a subgroup of patients with prior unstable angina or acute MI who have the highest identifiable risk of heart attack. Recent research suggest that some patients of a combined African and European lineage carry a variant of the gene encoding leukotriene A4 hydrolase (LTA4 hydrolase) that puts them at a three-fold greater risk for a heart attack. DG-031, licensed by deCODE Genetics, Inc. is designed to block the negative effects of the variant gene. The LTCAD study will examine the long-term safety and efficacy of DG-031. The trial is being conducted under a Special Protocol Assessment (SPA) with the US Food and Drug Administration (FDA).
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